DocumentCode
2484862
Title
FD4 and FD20 transport through epidermis by electroporation
Author
Hong, Wang ; Jiali, Bao
fYear
0
fDate
0-0 0
Firstpage
81
Lastpage
84
Abstract
Transdermal drug delivery is a novel delivery system, it is worth applying very much. In this paper we use FD4 and FD20 as model substance. Experiment date indicate that electroporation can effectively enhance transport FD4 and FD20 through skin, and also find that voltage, capacitance, molecular weight and different position of skin affect the macromolecule transport. Molecular weight of FD20 is 19,500 Da and it is more than of insulin whose is 5,800 Da, and then it is a potential to transport insulin through skin by electroporation
Keywords
bioelectric potentials; drug delivery systems; macromolecules; molecular weight; skin; FD20 transport; FD4 transport; capacitance; electroporation; epidermis; macromolecule transport; molecular weight; skin; transdermal drug delivery; voltage; Chemicals; Drug delivery; Educational institutions; Electrodes; Epidermis; Humans; Insulin; Skin; Temperature; Voltage; electroporation; macromolecule; transdermal drug delivery;
fLanguage
English
Publisher
ieee
Conference_Titel
Computer Architectures for Machine Perception, 2003 IEEE International Workshop on
Conference_Location
Hong Kong
Print_ISBN
0-7803-8612-4
Type
conf
DOI
10.1109/ISSMD.2004.1689566
Filename
1689566
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