Calibrating the photo-thermal response of magneto-fluorescent gold nanoshells

Author

Biswal, Nrusingh C. ; Ayala-Orzoco, Ciceron ; Halas, Naomi J. ; Joshi, Amit

Author_Institution

Dept. of Radiol., Baylor Coll. of Med., Houston, TX, USA

fYear

2011

fDate

Aug. 30 2011-Sept. 3 2011

Firstpage

4776

Lastpage

4779

Abstract

We report the photothermal response and Near Infrared (NIR) imaging sensitivities of magneto-fluorescent silica core gold nanocomplexes designed for molecular image guided thermal therapy of cancer. Approximately 160 nm Silica core gold nanoshells were designed to provide NIR fluorescent and Magnetic Resonance (MR) contrast by incorporating FDA approved dye indocyanine green (ICG) and iron-oxide within an outer silica epilayer. The imaging and therapeutic sensitivity, and the stability of fluorescence contrast for 12 microliters of suspension (containing approximately 7.9 × 10⁸ or 1.3 femtoMole nanoshells) buried at depths of 2-8 mm in tissue mimicking scattering media is reported.

Keywords

biomedical MRI; biomedical optical imaging; cancer; dyes; fluorescence spectroscopy; gold; hyperthermia; infrared imaging; iron compounds; magnetic particles; nanobiotechnology; nanocomposites; nanoparticles; photothermal effects; ICG; NIR fluorescent contrast; NIR imaging sensitivities; SiO₂-Au; SiO₂-FeO; cancer therapy; core-shell nanoparticles; fluorescence contrast stability; imaging sensitivity; indocyanine green; magnetic resonance contrast; magnetofluorescent gold nanoshells; molecular image guided thermal therapy; near infrared imaging sensitivities; outer silica epilayered iron oxide; photothermal response calibration; silica core-gold shell nanocomplexes; suspension; therapeutic sensitivity; tissue mimicking scattering media; Cancer; Gold; Medical treatment; Phantoms; Scattering; Silicon compounds; Calibration; Ferric Compounds; Fluorescence; Gold; Indocyanine Green; Magnetic Resonance Spectroscopy; Magnetics; Nanostructures;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE

Conference_Location

Boston, MA

ISSN

1557-170X

Print_ISBN

978-1-4244-4121-1

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2011.6091183

Filename

6091183