DocumentCode :
2490113
Title :
Design of a high sensitive double-gate field-effect transistor biosensor for DNA detection
Author :
Islam, Md Saiful ; Kouzani, Abbas Z.
Author_Institution :
Sch. of Eng., Deakin Univ., Geelong, VIC, Australia
fYear :
2011
fDate :
Aug. 30 2011-Sept. 3 2011
Firstpage :
4788
Lastpage :
4791
Abstract :
The study of interactions between organic biomolecules and semiconducting surfaces is an important consideration for the design and fabrication of field-effect-transistor (FET) biosensor. This paper demonstrates DNA detection by employing a double-gate field effect transistor (DGFET). In addition, an investigation of sensitivity and signal to noise ratio (SNR) is carried out for different values of analyte concentration, buffer ion concentration, pH, reaction constant, etc. Sensitivity, which is indicated by the change of drain current, increases non-linearly after a specific value (~1nM) of analyte concentration and decreases non-linearly with buffer ion concentration. However, sensitivity is linearly related to the fluidic gate voltage. The drain current has a significant effect on the positive surface group (-NH2) compared to the negative counterpart (-OH). Furthermore, the sensor has the same response at a particular value of pH (5.76) irrespective of the density of surface group, although it decreases with pH value. The signal to noise ratio is improved with higher analyte concentrations and receptor densities.
Keywords :
DNA; MOSFET; biosensors; molecular biophysics; DNA detection; FET biosensor design; FET biosensor fabrication; FET sensitivity; FET signal-noise ratio; analyte concentration; buffer ion concentration; drain current change; field effect transistor; fluidic gate voltage; high sensitivity double gate FET biosensor; organic biomolecule-semiconducting surface interactions; pH; positive surface group; reaction constant; Biosensors; DNA; FETs; Logic gates; Nanobioscience; Sensitivity; Signal to noise ratio; Biosensing Techniques; DNA; Kinetics; Models, Theoretical; Nucleic Acid Hybridization;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE
Conference_Location :
Boston, MA
ISSN :
1557-170X
Print_ISBN :
978-1-4244-4121-1
Electronic_ISBN :
1557-170X
Type :
conf
DOI :
10.1109/IEMBS.2011.6091186
Filename :
6091186
Link To Document :
بازگشت