Parametric and non-parametric models of short-term plasticity

Short-term plasticity (STP) was recorded with voltage-clamp technique and modeled with both parametric and nonparametric approaches. In the parametric approach, we simulated STP by calculating facilitation and refractory depression driven by presynaptic residual calcium. In the nonparametric approach, STP was modeled using Laguerre expansions of Volterra kernels. Our results showed that the 3^rd order non-parametric model sufficiently captured the nonlinearities of the parametric model.