Title :
Detecting failures of the glucose sensor-insulin pump system: Improved overnight safety monitoring for Type-1 diabetes
Author :
Facchinetti, Andrea ; Favero, Simone Del ; Sparacino, Giovanni ; Cobelli, Claudio
Author_Institution :
Dept. of Inf. Eng., Univ. of Padova, Padova, Italy
fDate :
Aug. 30 2011-Sept. 3 2011
Abstract :
New sensors for real-time continuous glucose monitoring (CGM) and pumps for continuous subcutaneous insulin infusion (CSII), possibly mounted on the same device, opened new scenarios for Type-1 diabetes treatment. However, possible failures of either CGM or CSII can expose diabetic patients to risks that can be dangerous especially overnight. In this contribution we present a proof-of-concept method, developed in a state-space context and implemented through a Kalman estimator, to detect in real time possible overnight failures of the sensor-pump system by simultaneously using CGM and CSII data. The method is tested on two simulated and one real subject. Results show that the method is able to correctly generate alerts for sensor-pump failures and stimulates further investigation on its development.
Keywords :
Kalman filters; biochemistry; biomedical equipment; chemical sensors; diseases; patient monitoring; patient treatment; pumps; skin; state-space methods; sugar; Kalman estimator; continuous subcutaneous insulin infusion; glucose sensor-insulin pump system; overnight safety monitoring; proof-of-concept method; real time continuous glucose monitoring; sensor-pump failure; sensor-pump system; state-space development; type-1 diabetes treatment; Diabetes; Frequency division multiplexing; Insulin; Kalman filters; Plasmas; Sensors; Sugar; Blood Glucose Self-Monitoring; Diabetes Mellitus, Type 1; Diagnosis, Computer-Assisted; Drug Therapy, Computer-Assisted; Equipment Failure; Equipment Failure Analysis; Humans; Insulin Infusion Systems; Patient Safety; Pattern Recognition, Automated; Reproducibility of Results; Safety Management; Sensitivity and Specificity;
Conference_Titel :
Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-4121-1
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2011.6091226
