Model-based analysis of deep brain stimulation of the thalamus

Author

McIntyre, Cameron C. ; Grill, Warren M. ; Sherman, David L. ; Thakor, Nitish V.

Author_Institution

Dept. of Biomed. Eng., Johns Hopkins Univ. Sch. of Med., Baltimore, MD, USA

Volume

3

fYear

2002

fDate

23-26 Oct. 2002

Firstpage

2047

Abstract

High-frequency (∼150 Hz) deep brain stimulation (DBS) represents a rapidly emerging therapy in the treatment of medically refractory movement disorders. However, fundamental questions remain about the effects of DBS at both the single cell and network levels. We determined the effects of high frequency stimulation of the thalamus using the combination of a finite element model of the DBS electrode, a multi-compartment cable model of a thalamocortical relay neuron, and a large-scale neural network model of the thalamocortical system. The results show that DBS has an excitatory effect on neural elements near the electrode, and this thalamic excitation results in increased cortical activity. This study supports the hypothesis of excitation-induced changes in network activity as a therapeutic mechanism of DBS.

Keywords

bioelectric phenomena; biomechanics; brain models; cellular biophysics; finite element analysis; neural nets; neurophysiology; 150 Hz; deep brain stimulation; excitatory effect; increased cortical activity; medically refractory movement disorders; model-based analysis; network level; neural elements; rapidly emerging therapy; single cell level; thalamocortical system; thalamus; therapeutic mechanism; Biomedical electrodes; Brain modeling; Brain stimulation; Finite element methods; Frequency; Large-scale systems; Medical treatment; Neurons; Relays; Satellite broadcasting;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1053160

Filename

1053160