Digital signal processing and modeling of the upstroke of action potential in cardiac myocytes

Author

Toyama, J. ; Anno, T. ; Taniguchi, A. ; Shirakawa, M. ; Usui, S.

Author_Institution

Res. Inst. of Environ. Med., Nagoya Univ., Japan

fYear

1991

fDate

23-26 Sep 1991

Firstpage

633

Lastpage

636

Abstract

A mathematical model was reconstructed based on the upstroke and sodium current separately recorded from enzymatically dispersed ventricular myocytes of a guinea pig, using the patch clamp technique. After holding the membrane potentials ranging from -120 to -60 mV for 500 ms, the upstroke was induced by applying the stimulus through the patch electrode with the constant latency to obtain voltage-dependence of availability for V_max. Phase plane plots (membrane potential vs. dV/dt) were used for optimization of a mathematical model. Experimental results could be reproduced by the model

Keywords

bioelectric potentials; cardiology; cellular biophysics; muscle; physiological models; signal processing; -120 to -60 mV; 500 ms; Na⁺ current; action potential upstroke; cardiac myocytes; digital signal processing; enzymatically dispersed ventricular myocytes; guinea pig; mathematical model; membrane potential; model optimization; patch clamp technique; patch electrode; phase plane plots; Biomembranes; Capacitance; Clamps; Digital signal processing; Electrodes; Finite impulse response filter; Kinetic theory; Low pass filters; Mathematical model; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology 1991, Proceedings.

Conference_Location

Venice

Print_ISBN

0-8186-2485-X

Type

conf

DOI

10.1109/CIC.1991.168991

Filename

168991