Title : 
Predicting drug absorption rates through human skin
         
        
            Author : 
Sun, Yi ; Lam, Lun Tak ; Moss, Gary ; Prapopoulou, Maria ; Adams, Rod ; Davey, Neil ; Gray, David ; Brown, Mark
         
        
            Author_Institution : 
Univ. of Hertfordshire, Hatfield, UK
         
        
        
        
        
        
            Abstract : 
Predicting the rate at which a substance will pass through human skin and into the bloodstream is a problem of current interest. We use Gaussian Process modeling to train a set of predictors using every combination of six molecular features. We find that only three of the features are needed for our best predictor. This result could be useful in the further analysis of skin permeability.
         
        
            Keywords : 
Gaussian distribution; absorption; biodiffusion; biomedical measurement; drugs; physiological models; skin; Gaussian process; bloodstream; drug absorption rates; human skin; skin permeability; Absorption; Chemicals; Gaussian processes; High definition video; Permeability; Skin; Training;
         
        
        
        
            Conference_Titel : 
Neural Networks (IJCNN), The 2010 International Joint Conference on
         
        
            Conference_Location : 
Barcelona
         
        
        
            Print_ISBN : 
978-1-4244-6916-1
         
        
        
            DOI : 
10.1109/IJCNN.2010.5596603