Title :
Metabolic profiling: definition and use in physiological state classification
Author :
Lee, K. ; Hwang, D. ; Yarmush, Martin L. ; Stephanopoulos, G.N.
Abstract :
Metabolic profiling analyses were performed on metabolite measurements and intracellular fluxes obtained in liver models of injury. Classification of physiological states by projection based discrimination improved with increasing metabolite measurement number and addition of fluxes.
Keywords :
biochemistry; biomedical measurement; cellular biophysics; liver; physiological models; physiology; statistical analysis; cellular homeostasis; increasing metabolite measurement number; injury; intracellular fluxes; liver failure; liver models; metabolic profiling; metabolite measurements; physiological state classification; physiological states; Biochemistry; Biological system modeling; Chemical analysis; Chemical engineering; Chemical technology; Extracellular; Hospitals; Injuries; Liver; Principal component analysis;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1053246
