Molecular specific contrast agents to enhance optical imaging of precancers

Author

Sokolov, Konstantin ; Aaron, Jesse ; Pavlova, Ina ; Lotaw, R. ; Malpica, Anais ; Foller, M. ; Richards-Kortum, Rebecca

Author_Institution

Dept. of Biomed. Eng., Texas Univ., Austin, TX, USA

Volume

3

fYear

2002

fDate

23-26 Oct. 2002

Firstpage

2327

Abstract

In this paper, we bring together the advances of in vivo optical imaging and modern nano-chemistry to permit optical imaging with molecular specificity. We present optically interrogated contrast agents based on metal nanocrystals attached to probe molecules with a high affinity to a specific biomarker on the surface of epithelial cancer cells. We demonstrated that unique optical properties of metal nanoparticles can be used to develop novel optically-interrogatable contrast agents for confocal reflectance imaging of pre-cancers.

Keywords

biomedical optical imaging; cancer; cellular biophysics; image enhancement; molecular biophysics; reflectivity; Au; cancer imaging; confocal reflectance imaging; contrast agents; epithelial cancer cells; gold nanoparticles; in vivo optical imaging; metal nanocrystals; modern nanochemistry; molecular specificity; optically-interrogatable contrast agents; probe molecules; Biomarkers; Biomedical optical imaging; Cancer; Gold; In vivo; Nanoparticles; Optical imaging; Optical scattering; Resonance light scattering; Silver;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1053305

Filename

1053305