DocumentCode :
2494173
Title :
A CMOS Image Sensor for Fluorescence Lifetime Imaging
Author :
Yoon, Hyung-June ; Kawahito, Shoji
Author_Institution :
Shizuoka Univ., Hamamatsu
fYear :
2006
fDate :
22-25 Oct. 2006
Firstpage :
400
Lastpage :
403
Abstract :
In this paper, a CMOS image sensor for fluorescence lifetime imaging (FLIM) is presented. The fluorescence lifetime is a powerful tool to analyze molecules because the fluorescence lifetime reflects a molecule´s structure, dynamics, and environments. The proposed CMOS FLIM sensor consists of pixel array to realize the sifting ability for fluorescence, noise canceling column readout amplifiers, and output buffers. The pixel has a photodiode and an image intensifier to sift fluorescence from the excited light pulses. A prototype CMOS FLIM sensor with 320(H) times 80(V) pixels is designed and implemented in 0.18 mum CMOS technology. The results show that the CMOS FLIM sensor has the ability to sift fluorescence from the excited light pulses using a blue and an ultraviolet light-emitting diodes. It also shows that the CMOS FLIM sensor can measure the lifetime in a wide range of fluorescence lifetime.
Keywords :
CMOS image sensors; fluorescence; light emitting diodes; molecular configurations; photodiodes; readout electronics; CMOS FLIM sensor; CMOS image sensor; fluorescence lifetime imaging; molecule analysis; molecule structure; noise canceling column; photodiode; readout amplifiers; size 0.18 micron; ultraviolet light emitting diodes; CMOS image sensors; CMOS technology; Fluorescence; Image intensifiers; Noise cancellation; Photodiodes; Pixel; Pulse amplifiers; Sensor arrays; Working environment noise;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Sensors, 2006. 5th IEEE Conference on
Conference_Location :
Daegu
ISSN :
1930-0395
Print_ISBN :
1-4244-0375-8
Electronic_ISBN :
1930-0395
Type :
conf
DOI :
10.1109/ICSENS.2007.355490
Filename :
4178642
Link To Document :
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