Title :
Lithium Tantalate Surface Acoustic Wave Sensors for Bio-Analytical Applications
Author :
Malavé, A. ; Schlecht, U. ; Gronewold, T.M.A. ; Perpeet, M. ; Tewes, M.
Author_Institution :
Center of Adv. Eur. Studies & Res. (caesar), Bonn
Abstract :
A novel chip-based measurement system for marker-free detection of affinity and molecular interaction kinetics has been developed. Lithium tantalate (LiTaO3) based Love-wave sensors are utilized as an alternative to quartz as substrate material in order to improve both the sensitivity and the limit-of-detection (LOD). Monitoring the coupling of thrombin to its antibody at low concentrations 1 nM and 10 nM showed phase changes of Deltaphi = 0.10deg and 0.35deg, respectively, for an active sensor area of 5.6 mm2. We have found that the estimated detection limit for thrombin is on the order of 0.18 nM for our LiTaO3 sensors.
Keywords :
biosensors; lithium compounds; surface acoustic wave sensors; tantalum compounds; LiTaO3; Love-wave sensors; bio-analytical applications; chip-based measurement system; limit-of-detection; lithium tantalate surface acoustic wave sensors; marker-free detection; molecular interaction kinetics; quartz; substrate material; thrombin coupling; Acoustic measurements; Acoustic sensors; Acoustic signal detection; Acoustic waves; Biological materials; Biosensors; Kinetic theory; Lithium compounds; Semiconductor device measurement; Surface acoustic waves;
Conference_Titel :
Sensors, 2006. 5th IEEE Conference on
Conference_Location :
Daegu
Print_ISBN :
1-4244-0375-8
Electronic_ISBN :
1930-0395
DOI :
10.1109/ICSENS.2007.355540
