Title :
Amyloid-ss Dynamics Correlate with Neurological Status in the Injured Human Brain
Author :
Brody, David L. ; Esparza, Thomas J. ; Magnoni, Sandra ; Stocchetti, Nino ; Schwetye, Kate E. ; Zipfel, Greg J. ; Spinner, Michael ; Holtzman, David M.
Author_Institution :
Dept. of Neurology, Washington Univ., St Louis, MO, USA
Abstract :
The amyloid-beta peptide (Abeta) plays a central pathophysiological role in Alzheimer´s disease, but virtually nothing is known about the concentration and dynamics of this secreted peptide in the extracellular space of the human brain. We used intracerebral microdialysis to obtain serial brain interstitial fluid (ISF) samples in 18 patients who were undergoing invasive intracranial monitoring after acute brain injury. We found a strong positive correlation between changes in brain ISF Abeta levels and neurological status, and correlations with other cerebral physiological and metabolic abnormalities reflecting depressed neuronal function. Such dynamics fit well with the hypothesis that neuronal activity regulates extracellular Abeta concentration.
Keywords :
biochemistry; brain; cellular biophysics; diseases; neurophysiology; patient monitoring; proteins; wounds; Alzheimer disease; amyloid-beta peptide dynamics; brain ISF Abeta level; extracellular Abeta concentration; hypothesis; injured human brain; intracerebral microdialysis; invasive intracranial monitoring; metabolic abnormality; neurological status; pathophysiological role; serial brain interstitial fluid sample; Alzheimer´s disease; Amino acids; Anesthesia; Brain injuries; Extracellular; Fluid dynamics; Humans; Nervous system; Patient monitoring; Peptides;
Conference_Titel :
Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-2901-1
Electronic_ISBN :
978-1-4244-2902-8
DOI :
10.1109/ICBBE.2009.5162305
