Amyloid-ss Dynamics Correlate with Neurological Status in the Injured Human Brain

Author

Brody, David L. ; Esparza, Thomas J. ; Magnoni, Sandra ; Stocchetti, Nino ; Schwetye, Kate E. ; Zipfel, Greg J. ; Spinner, Michael ; Holtzman, David M.

Author_Institution

Dept. of Neurology, Washington Univ., St Louis, MO, USA

fYear

2009

fDate

11-13 June 2009

Firstpage

1

Lastpage

3

Abstract

The amyloid-beta peptide (Abeta) plays a central pathophysiological role in Alzheimer´s disease, but virtually nothing is known about the concentration and dynamics of this secreted peptide in the extracellular space of the human brain. We used intracerebral microdialysis to obtain serial brain interstitial fluid (ISF) samples in 18 patients who were undergoing invasive intracranial monitoring after acute brain injury. We found a strong positive correlation between changes in brain ISF Abeta levels and neurological status, and correlations with other cerebral physiological and metabolic abnormalities reflecting depressed neuronal function. Such dynamics fit well with the hypothesis that neuronal activity regulates extracellular Abeta concentration.

Keywords

biochemistry; brain; cellular biophysics; diseases; neurophysiology; patient monitoring; proteins; wounds; Alzheimer disease; amyloid-beta peptide dynamics; brain ISF Abeta level; extracellular Abeta concentration; hypothesis; injured human brain; intracerebral microdialysis; invasive intracranial monitoring; metabolic abnormality; neurological status; pathophysiological role; serial brain interstitial fluid sample; Alzheimer´s disease; Amino acids; Anesthesia; Brain injuries; Extracellular; Fluid dynamics; Humans; Nervous system; Patient monitoring; Peptides;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on

Conference_Location

Beijing

Print_ISBN

978-1-4244-2901-1

Electronic_ISBN

978-1-4244-2902-8

Type

conf

DOI

10.1109/ICBBE.2009.5162305

Filename

5162305