Anti-inflammatory Activity of Salvianic acid A through the Inhibition of Nuclear Factor-kappaB Activation in Peritoneal Macrophage

Author

Yuan, Jun ; Yao, Ji-Hong ; Zhou, Qin ; Hu, Xiao-Wei ; Chu, Liang ; Tian, Xiao-Feng

Author_Institution

Dept. of Pharmacology, Dalian Med. Univ., Dalian, China

fYear

2009

fDate

11-13 June 2009

Firstpage

1

Lastpage

4

Abstract

In the present study, we examined the anti-inflammatory properties of Salvianic acid A (SAA) in peritoneal macrophage induced by lipopolysaccharide (LPS). SAA inhibited the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in LPS-induced peritoneal macrophages and blocked protein expressions of inducible nitric oxide synthase (iNOS) and matrix metalloproteinase-9 (MMP-9). In addition, the LPS-induced nuclear factor-kappa B (NF-kappaB) activation was suppressed by SAA treatment.

Keywords

biochemistry; cellular biophysics; molecular biophysics; nitrogen compounds; organic compounds; tumours; IL-6; LPS induced peritoneal macrophages; MMP-9; NO; TNF alpha; blocked protein expressions; iNOS; inducible nitric oxide synthase; interleukin-6; lipopolysaccharide; matrix metalloproteinase-9; nitric oxide production inhibition; nuclear factor kappaB activation inhibition; salvianic acid antiinflammatory activity; tumor necrosis factor alpha; Analysis of variance; Biological materials; Biomedical materials; Connective tissue; Diseases; Hospitals; Neoplasms; Production; Proteins; Surgery;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on

Conference_Location

Beijing

Print_ISBN

978-1-4244-2901-1

Electronic_ISBN

978-1-4244-2902-8

Type

conf

DOI

10.1109/ICBBE.2009.5162374

Filename

5162374