Automated Synthesis of 18F-Fluoroacetate Using Explora FDG4 Module

Author

Sun, Li-Quan ; Luo, Ai-qin ; Fujibayashi, Yasuhisa

Author_Institution

Sch. of Life Sci. & Technol., Beijing Inst. of Technol., Beijing, China

fYear

2009

fDate

11-13 June 2009

Firstpage

1

Lastpage

4

Abstract

As radio-labeled acetate is a good candidate to detect glial metabolism in brains and prostate cancer, ethyl and sodium [¹⁸F] fluoroacetates were utilized in clinical PET check. A simple and fast method for preparation of ethyl and sodium [¹⁸F]fluoroacetates using Explora FDG₄ module has been established. By this development, it has become possible to obtain ethyl and sodium [¹⁸F] fluoroacetate in a short synthesis time of 39 and 43 min and with a reproducible radiochemical yield of 49.6 plusmn 4.7% and 43.1 plusmn 5.2%, (decay corrected). The radiochemical purity of ethyl and sodium [¹⁸F] fluoroacetates were more than 95%.

Keywords

biomedical materials; organic compounds; positron emission tomography; radioactive tracers; ¹⁸F fluoroacetate automated synthesis; Explora FDG4 module; brain; clinical PET; ethyl ¹⁸F fluoroacetate preparation; glial metabolism detection; prostate cancer; radiochemical yield; radiolabeled acetate; sodium ¹⁸F fluoroacetate preparation; time 39 min; time 43 min; Biochemistry; Biomedical imaging; Cancer detection; Detectors; Neoplasms; Positron emission tomography; Prostate cancer; Radiometry; Solvents; Water;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on

Conference_Location

Beijing

Print_ISBN

978-1-4244-2901-1

Electronic_ISBN

978-1-4244-2902-8

Type

conf

DOI

10.1109/ICBBE.2009.5162426

Filename

5162426