DocumentCode :
2501568
Title :
Continuous arterial spin labeling of mouse cerebral blood flow using an actively-detuned two-coil system at 9.4T
Author :
Lei, Hongxia ; Pilloud, Yves ; Magill, Arthur W. ; Gruetter, Rolf
Author_Institution :
Lab. of Functional & Metabolic Imaging, EPFL-SB-IPSB-LIFMET, Lausanne, Switzerland
fYear :
2011
fDate :
Aug. 30 2011-Sept. 3 2011
Firstpage :
6993
Lastpage :
6996
Abstract :
Among numerous magnetic resonance imaging (MRI) techniques, perfusion MRI provides insight into the passage of blood through the brain´s vascular network non-invasively. Studying disease models and transgenic mice would intrinsically help understanding the underlying brain functions, cerebrovascular disease and brain disorders. This study evaluates the feasibility of performing continuous arterial spin labeling (CASL) on all cranial arteries for mapping murine cerebral blood flow at 9.4T. We showed that with an active-detuned two-coil system, a labeling efficiency of 0.82±0.03 was achieved with minimal magnetization transfer residuals in brain. The resulting cerebral blood flow of healthy mouse was 99±26mL/100g/min, in excellent agreement with other techniques. In conclusion, high magnetic fields deliver high sensitivity and allowing not only CASL but also other MR techniques, i.e. 1H MRS and diffusion MRI etc, in studying murine brains.
Keywords :
biomedical MRI; blood vessels; brain; diseases; haemodynamics; magnetisation; physiological models; actively-detuned two-coil system; blood passage; continuous arterial spin labeling; cranial arteries; disease models; labeling efficiency; magnetic flux density 9.4 T; magnetic resonance imaging; magnetization transfer; mouse cerebral blood flow; murine brains; perfusion MRI; transgenic mice; Blood flow; Coils; In vivo; Labeling; Magnetic resonance imaging; Mice; Animals; Artifacts; Blood-Brain Barrier; Brain; Brain Mapping; Cerebrovascular Circulation; Image Processing, Computer-Assisted; Magnetic Fields; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; Models, Anatomic; Models, Statistical; Reproducibility of Results; Spin Labels;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE
Conference_Location :
Boston, MA
ISSN :
1557-170X
Print_ISBN :
978-1-4244-4121-1
Electronic_ISBN :
1557-170X
Type :
conf
DOI :
10.1109/IEMBS.2011.6091768
Filename :
6091768
Link To Document :
بازگشت