Simulating electrical stimulation of degenerative retinal ganglion cells with bi-phasic pulse trains

Author

Kameneva, Tatiana ; Grayden, David B. ; Meffin, Hamish ; Burkitt, Anthony N.

Author_Institution

Dept. of Electr. & Electron. Eng., Univ. of Melbourne, Melbourne, VIC, Australia

fYear

2011

fDate

Aug. 30 2011-Sept. 3 2011

Firstpage

7103

Lastpage

7106

Abstract

The aim of this work was to investigate how retinal ganglion cells (RGCs) respond to repetitive electrical stimulation in degenerative retina. The response of modeled ON and OFF cells was examined to bi-phasic pulse train stimulation of varying frequencies. Previously developed models of RGCs were extended to include an experimentally observable balance of excitatory and inhibitory currents in degenerative retina. The phenomena of fading and dark phosphenes with retinal implants were investigated. A hypothesis for a mechanism contributing to these phenomena was formulated.

Keywords

bioelectric phenomena; cellular biophysics; eye; physiological models; prosthetics; bi-phasic pulse train stimulation; dark phosphenes; degenerative retina; degenerative retinal ganglion cells; electrical stimulation; excitatory current; fading phenomena; inhibitory current; retinal implants; Electrical stimulation; Fading; Implants; Mathematical model; Neurons; Numerical models; Retina; Action Potentials; Algorithms; Computer Simulation; Electric Stimulation; Equipment Design; Humans; Models, Statistical; Models, Theoretical; Neurodegenerative Diseases; Photic Stimulation; Retina; Retinal Ganglion Cells; Signal Processing, Computer-Assisted; Synapses;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE

Conference_Location

Boston, MA

ISSN

1557-170X

Print_ISBN

978-1-4244-4121-1

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2011.6091795

Filename

6091795