Author_Institution :
Med. Coll. of Chinese people´s Armed Police Force, TianJin Key Lab. of Occupational & Environ. Hazards Biomarkers, Tianjin, China
Abstract :
To evaluate cytokine network of pulmonary fibrosis. A systematic literature search of EMBASE, MEDLINE, Cochrane Library was conducted through December 2007. Then potential regulatory pathway of cytokines was analyzed with a cubic spline intepolation and a linear differential model. The cytokines of silicosis fibrosis tissue were identified by meta-analysis. The related cytokines participated pulmonary fibrosis were gamma-IFN, IL-10, IL-13, IL-18, IL-4, IL-5, IL-6, IL-8, IGF-1, MCP-l, PDGF, TGF-beta1, TNF-alpha, MMP-2, MMP-9, EGF by meta analysis. The key cytokines of regulated pathway nodes were y-IFN , IL-10, IL-13, IL-18, IL-6, IGF-1, PDGF, TGF-beta1, TNF-alpha. The cytokines networks of pulmonary fibrosis were composed of the key cytokines, but the other cytokines weren´t in the networks due to minor effectiveness induced pulmonary fibrosis or merely inflammatory effectiveness.
Keywords :
biological tissues; diseases; interpolation; linear differential equations; lung; proteins; splines (mathematics); Cochrane Library; EMBASE; MEDLINE; cubic spline intepolation; cytokine network; linear differential model; meta-analysis; potential regulatory pathway; pulmonary fibrosis; silicosis fibrosis tissue; Data mining; Differential equations; Hazards; Independent component analysis; Interpolation; Libraries; Performance analysis; Predictive models; Silicon compounds; Spline;
