Title :
Effect of ceria nanoparticles synthesis on their cytotoxicity against CaCo2 Cells in vitro
Author :
Yelken, Gulnihal O.
Author_Institution :
Muhendislik Fak., Kimya Muhendisligi Bolumu, Izmir Yuksek Teknol. Enstitusu, Izmir, Turkey
Abstract :
In recent year´s cerium oxide has been used productively in various engineering and biological applications, such as solid oxide fuel cells, catalytic materials, solar cells and biomedical applications as biological antioxidants [1-4]. Aim of this study is to investigate effects of synthesis conditions of nanoceria on cytotoxicity against CaCo2 (human colon adenocar-cinoma) Cells in vitro. The morphological and structural characterization of ceria nanopowders were performed by X-Ray Diffraction (XRD), Fourier Transform Infrared Spectra (FTIR), size distribution, electrokinetic analysis (zeta potential measurements), surface area. Cytotoxicity test using colon cancer cells showed that nanoceria have no cytotoxic effect against Caco-2 cells at low concentration and cytotoxicity change with respect to synthesis conditions.
Keywords :
Fourier transform infrared spectra; X-ray diffraction; cancer; cellular biophysics; cerium compounds; electrochemical analysis; electrokinetic effects; nanofabrication; nanomedicine; nanoparticles; spectrochemical analysis; toxicology; CaCo2 cells; CeO2; FTIR; Fourier Transform Infrared Spectra; X-Ray Diffraction; XRD; biological antioxidants; biological applications; biomedical applications; catalytic materials; ceria nanoparticle synthesis; ceria nanopowders; cerium oxide; colon cancer cells; cytotoxic effect; cytotoxicity test; electrokinetic analysis; human colon adenocar-cinoma; morphological characterization; nanoceria; size distribution; solar cells; solid oxide fuel cells; structural characterization; surface area; synthesis condition; zeta potential measurements; Abstracts; Biomedical measurement;
Conference_Titel :
Biomedical Engineering Meeting (BIYOMUT), 2014 18th National
Conference_Location :
Istanbul
DOI :
10.1109/BIYOMUT.2014.7026355