Expression of Human Differentiated Embryo-Chondrocyte Expressed Gene 1 in Gastric Carcinoma and Its Correlation with STAT3

Author

Zheng, Yan ; Jia, Yanfei ; Li, Binbin ; Wang, Min ; Xiao, Dongjie ; Wang, Yunshan

Author_Institution

Central Lab., Shandong Univ., Jinan, China

fYear

2009

fDate

11-13 June 2009

Firstpage

1

Lastpage

4

Abstract

DEC1, also known as SHARP-2 or Stral3, is an important molecule in embryonic differentiation and a bHLH type transcriptional regulator. It has recently been identified to be abundantly expressed in several human tumors and might play an important role in tumor development. But its expression in gastric carcinoma is unknown. In this study we show that DEC1 was frequently expressed in six gastric carcinoma cell lines with different background and tumor tissues from patients with gastric carcinoma. A significant association of DEC1 expression with STAT3 expression was also proved. These findings suggest that DEC1 is strongly related with gastric carcinoma; it might play its role in tumor development through STAT3-signaling pathway.

Keywords

biochemistry; biological organs; cancer; cellular biophysics; genetics; molecular biophysics; tumours; DEC1 expression; SHARP-2; STAT3-signaling pathway; Stral3 molecule; bHLH type transcriptional regulator; embryo-chondrocyte expressed gene 1; gastric carcinoma cell lines; human tumor tissues; immunohistochemistry; Cancer; Embryo; Hospitals; Humans; Immune system; Lungs; Neoplasms; Oncological surgery; Proteins; Regulators;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on

Conference_Location

Beijing

Print_ISBN

978-1-4244-2901-1

Electronic_ISBN

978-1-4244-2902-8

Type

conf

DOI

10.1109/ICBBE.2009.5162836

Filename

5162836