Title :
Feature Selection for Tandem Mass Spectrum Quality Assessment via Sparse Logistical Regression
Author :
Ding, Jiarui ; Wu, Fang-Xiang
Author_Institution :
Dept. of Mech. Eng., Univ. of Saskatchewan, Saskatoon, SK, Canada
Abstract :
Machine learning algorithms are widely used for quality assessment of tandem mass spectra based on a number of features. However, it is still unclear which features are most relevant to the quality of tandem mass spectra. In this paper, a sparse logistical regression method is proposed for selecting the most relevant features from those features found in the literature. To investigate the performance of the proposed method, experiments are conducted on two datasets. The results show the sparse logistical regression model can effectively select a small number of highly relevant features for tandem mass spectrum quality assessment.
Keywords :
biological techniques; biology computing; learning (artificial intelligence); mass spectra; mass spectrometers; regression analysis; feature selection; machine learning; quality assessment; sparse logistical regression; tandem mass spectrum; Biological system modeling; Biomedical engineering; Biomedical measurements; Charge measurement; Current measurement; Machine learning algorithms; Mass spectroscopy; Peptides; Proteins; Quality assessment;
Conference_Titel :
Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-2901-1
Electronic_ISBN :
978-1-4244-2902-8
DOI :
10.1109/ICBBE.2009.5162855