Title :
Gene Network Study Revealed Molecular Links Among Genes for Alcohol Metabolism and Breast Cancer Susceptibility
Author :
Meng, Liangyu ; Li, Pengpeng ; Wang, YunWang ; Wang, Changlu ; Wang, Zhiwei ; Zhang, Zhizhou
Author_Institution :
Teda Bio-X Center for Syst. Biotechnol., Tianjin Univ. of Sci. & Technol., Tianjin, China
Abstract :
The relationship between alcohol consumption and onsets of breast cancer (BC) keeps obscure. A local gene network (LGN) was constructed using 24 breast cancer susceptibility genes that participate in known signal transduction pathways. It was found that the LGN was able to directly link several genes (ALDH, ADH1B and HDAC1) that have approved functions in alcohol metabolism. Further analysis indicated that the above three genes were associated with each other by other genes and metabolic molecules. Microarray data from 106 individual breast cancer patients and 4 normal people indicated that several key alcohol metabolism related genes were de-regulated and would induce genotypic combinations with the BC-specific LGN.
Keywords :
biochemistry; cancer; genetics; molecular biophysics; ADH1B; ALDH; HDAC1; alcohol consumption; alcohol metabolism; breast cancer onset; breast cancer susceptibility; local gene network; molecular links; signal transduction pathways; Biochemistry; Biotechnology; Breast cancer; Clinical diagnosis; DNA; Diseases; Displays; Medical treatment; Signal processing; Visualization;
Conference_Titel :
Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-2901-1
Electronic_ISBN :
978-1-4244-2902-8
DOI :
10.1109/ICBBE.2009.5162878
