Generalised predictive control (GPC) with prespecified set-points in clinical anaesthesia

This particular study concerns the application of the generalised predictive control (GPC) algorithm using the concept of prespecified set-points in clinical anaesthesia. The study reveals that the SISO GPC version behaves very well under these circumstances and displays good robustness properties when mismatch conditions between the actual and assumed set-point profiles are considered. Moreover, when the scheme is extended to enhance a multivariable structure involving simultaneous control of muscle relaxation together with unconsciousness using blood pressure measurements, the levels of interaction from one channel to the other one can be considerably reduced without great compromise on other characteristics such as transient response and speed making therefore this whole concept of set-point prespecification an attractive candidate for future clinical trials