Title :
Modeling of ATM Accumulation and ATM-Mediated Oscillation of p53
Author :
Guo Zhi-guang ; Zhao Tong-Jun ; Yuan Chang-qing ; Liu Hui ; Yang Yue ; Yu Kun ; Zeng Ling-bo ; Zhan Yong
Author_Institution :
Inst. of Biophys., Hebei Univ. of Technol., Tianjin, China
Abstract :
A dynamical model to study the accumulation of ATM is proposed in this work. The ATM can accumulate either with low level of DSBs and presence of NBS1 proteins in cells, or with high level of DSBs and absence of NBS1. Both the two ways trigger the cell damage repair system. The interaction in p53 networks responding to DNA damage is discovered in many researches, but the mechanism of initiating oscillation remains unclear. We examine a model shows that the ATM-NBS1 feedback loop exhibits bistability. The bistability has essential roles in the mechanism of initiate oscillation.
Keywords :
DNA; cellular biophysics; molecular biophysics; proteins; ATM accumulation modeling; ATM-NBS1 feedback loop; ATM-mediated oscillation; DNA damage; DNA double strand; NBS1 protein; ataxia telangiectasia mutated gene; cell damage repair system; p53 protein network interaction; Amino acids; Asynchronous transfer mode; Biophysics; DNA; Feedback loop; Neoplasms; Proteins; Recruitment; Relays; Switches;
Conference_Titel :
Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-2901-1
Electronic_ISBN :
978-1-4244-2902-8
DOI :
10.1109/ICBBE.2009.5163075
