Modeling of ATM Accumulation and ATM-Mediated Oscillation of p53

Author

Guo Zhi-guang ; Zhao Tong-Jun ; Yuan Chang-qing ; Liu Hui ; Yang Yue ; Yu Kun ; Zeng Ling-bo ; Zhan Yong

Author_Institution

Inst. of Biophys., Hebei Univ. of Technol., Tianjin, China

fYear

2009

fDate

11-13 June 2009

Firstpage

1

Lastpage

4

Abstract

A dynamical model to study the accumulation of ATM is proposed in this work. The ATM can accumulate either with low level of DSBs and presence of NBS1 proteins in cells, or with high level of DSBs and absence of NBS1. Both the two ways trigger the cell damage repair system. The interaction in p53 networks responding to DNA damage is discovered in many researches, but the mechanism of initiating oscillation remains unclear. We examine a model shows that the ATM-NBS1 feedback loop exhibits bistability. The bistability has essential roles in the mechanism of initiate oscillation.

Keywords

DNA; cellular biophysics; molecular biophysics; proteins; ATM accumulation modeling; ATM-NBS1 feedback loop; ATM-mediated oscillation; DNA damage; DNA double strand; NBS1 protein; ataxia telangiectasia mutated gene; cell damage repair system; p53 protein network interaction; Amino acids; Asynchronous transfer mode; Biophysics; DNA; Feedback loop; Neoplasms; Proteins; Recruitment; Relays; Switches;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on

Conference_Location

Beijing

Print_ISBN

978-1-4244-2901-1

Electronic_ISBN

978-1-4244-2902-8

Type

conf

DOI

10.1109/ICBBE.2009.5163075

Filename

5163075