Vibrational spectroscopic analysis of theophylline in a pharmaceutical granulation process using near-, mid- and far-infrared/terahertz spectroscopy

Author

Sakamoto, Tomoaki ; Sasaki, Tetsuo ; Nishizawa, Jun-ichi ; Katori, Noriko ; Hiyama, Yukio ; Okuda, Haruhiro

Author_Institution

Div. of Drugs, Nat. Inst. of Health Sci., Tokyo, Japan

fYear

2012

fDate

23-28 Sept. 2012

Firstpage

1

Lastpage

2

Abstract

Vibrational spectroscopic analysis of theophylline in a wet granulation process was performed. An anhydride was converted to a monohydrate during the granulation and a dehydration of monohydrate progressed during the drying process. A C-N stretching would be affected by an interaction between theophylline and a binder under a wet granulation process.

Keywords

drying; infrared spectroscopy; pharmaceutical technology; terahertz spectroscopy; vibrations; wetting; C-N stretching; anhydride; binder; drying process; far-infrared spectroscopy; far-terahertz spectroscopy; mid-infrared spectroscopy; mid-terahertz spectroscopy; monohydrate dehydration; near-infrared spectroscopy; near-terahertz spectroscopy; pharmaceutical granulation process; theophylline vibrational spectroscopic analysis; wet granulation process; Absorption; Atmospheric measurements; Bonding; Hydrogen; Pharmaceuticals; Spectroscopy; Temperature measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Infrared, Millimeter, and Terahertz Waves (IRMMW-THz), 2012 37th International Conference on

Conference_Location

Wollongong, NSW

ISSN

2162-2027

Print_ISBN

978-1-4673-1598-2

Electronic_ISBN

2162-2027

Type

conf

DOI

10.1109/IRMMW-THz.2012.6380423

Filename

6380423