Title :
Preparation of Calcium Phosphate-Based Bone Repair Materials
Author :
Liu, Hua ; Wang, Jing
Author_Institution :
Coll. of Med. Inf. Eng., Guangdong Pharm. Univ., Guangzhou, China
Abstract :
We developed a calcium phosphate cement that could be molded into any desired shape due to its chewing-gum-like consistency after mixing. The powder component of the cement consists of tricalcium phosphate (TCP). The liquid component consists of chitosan, citric acid and glucose solution. In this study, we used four groups of cement to investigate the mechanical properties and biocompatibility of the new biomaterial in vivo. The setting times of the cements were 5-30 min. X-ray diffraction analysis showed that the products were hydroxyapatite (HA) and dicalcium phosphate anhydrous. When the concentration of citric acid was increased, the compressive strength of specimen increased. The animal experiments showed that the material was nontoxic and osteoinductivity.
Keywords :
X-ray diffraction; biomedical materials; bone; calcium compounds; cements (building materials); Ca10(PO4)6(OH)2; X-ray diffraction; biocompatibility; biomaterial; bone repair materials; cement; chitosan; citric acid; dicalcium phosphate anhydrous; glucose solution; hydroxyapatite; mechanical properties; mixing; osteoinductivity; time 5 min to 30 min; tricalcium phosphate; Animals; Bones; Building materials; Calcium; In vivo; Mechanical factors; Powders; Shape; Sugar; X-ray diffraction;
Conference_Titel :
Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-2901-1
Electronic_ISBN :
978-1-4244-2902-8
DOI :
10.1109/ICBBE.2009.5163234