MIGRATION AND PROLIFERATION ANALYSIS FOR BLADDER CANCER CELLS

Author

Said, Asaad F. ; Karam, Lina J. ; Berens, Michael E. ; Lacroix, Zoé ; Renaut, Rosemary A.

Author_Institution

Dept. of Electr. Eng., Arizona State Univ., Tempe, AZ

fYear

2007

fDate

12-15 April 2007

Firstpage

320

Lastpage

323

Abstract

This paper presents a cell evolution analysis (CEA) scheme for bladder cancer cells. The proposed scheme consists of a cell migration analysis component for computing the overall migration rate of the cell cluster, and a cell proliferation analysis component based on counting the individually segmented cells within the cell cluster at different time points. The proposed CEA scheme performs well for images with poor contrast and high cell concentrations, even when the cells are overlapping and small. Results are presented to illustrate the performance of the proposed scheme

Keywords

biological organs; cancer; cell motility; image segmentation; medical image processing; tracking; bladder cancer cells; cell cluster; cell counting; cell evolution analysis; cell migration analysis; cell migration rate; cell proliferation analysis; high cell concentrations; poor-contrast images; segmented cells; Background noise; Bladder; Cancer; Clustering algorithms; Genomics; Image analysis; Image processing; Image segmentation; Microscopy; Stem cells;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Imaging: From Nano to Macro, 2007. ISBI 2007. 4th IEEE International Symposium on

Conference_Location

Arlington, VA

Print_ISBN

1-4244-0672-2

Electronic_ISBN

1-4244-0672-2

Type

conf

DOI

10.1109/ISBI.2007.356853

Filename

4193287