Title :
Immunosensor for C-reactive protein using anti-CRP monoclonal antibody and its F(AB´)2 fragment immobilized quartz crystal microbalance
Author :
Kurosawa, S. ; Nakamura, M. ; Aizawa, H. ; Park, J.-W. ; Tozuka, M. ; Kobayashi, K. ; Yamada, K. ; Hirata, M.
Author_Institution :
Nat. Inst. of Adv. Ind. Sci. & Technol. (AIST), Ibaraki, Japan
Abstract :
We present the detection method of C-reactive protein (CRP) using anti-CRP antibody and its F(ab´)2 fragment immobilized quartz crystal microbalance (QCM). The present QCM method is detectable in the range 1 ng/dL to 100 μg/dL of CRP concentration.
Keywords :
biosensors; microbalances; molecular biophysics; proteins; C-reactive protein concentration; anti-C-reactive protein monoclonal antibody; detection method; fragment immobilized quartz crystal microbalance; immunosensor; Aging; Amino acids; Electrodes; Frequency measurement; Gold; Humans; Immune system; Nitrogen; Proteins; Surface treatment;
Conference_Titel :
Frequency Control Symposium and PDA Exhibition, 2002. IEEE International
Print_ISBN :
0-7803-7082-1
DOI :
10.1109/FREQ.2002.1075891
