ALGORITHM FOR IN VIVO CW FLUORESCENCE DIFFUSE OPTICAL TOMOGRAPHY TAKING INTO ACCOUNT OPTICAL HETEROGENEITIES OF BIOLOGICAL TISSUES AND THE SHAPE OF THE ANIMAL

Author

Hervé, L. ; Koenig, A. ; Silva, A. Da ; Berger, M. ; Boutet, J. ; Peltié, P. ; Rizo, P. ; Dinten, J.M.

Author_Institution

CEA-LETI, Grenoble

fYear

2007

fDate

12-15 April 2007

Firstpage

812

Lastpage

815

Abstract

A fluorescence enhanced diffuse optical tomography algorithm taking into account the optical heterogeneities is presented. It is suitable for continuous wave acquisitions and naturally handles complex shaped object. Therefore, it allows in vivo studies of small animals injected with target-specific fluorescent probes without immersion fluid. A comparison with previous methods conducted on simulations is presented. A validation experiment performed on the same mouse at different stage of lung tumors growth shows the ability of the system to be used for biological studies

Keywords

bio-optics; biological tissues; biomedical optical imaging; fluorescence; image reconstruction; lung; medical image processing; optical tomography; tumours; animal shape; biological tissues; complex shaped object; continuous wave acquisitions; continuous wave optical tomography; diffuse optical tomography; fluorescence; fluorescence reconstruction; in vivo optical tomography; lung tumors; mouse; optical heterogeneities; small animals; target-specific fluorescent probes; tumor growth; Animals; Biological system modeling; Biological tissues; Biomedical optical imaging; Fluorescence; In vivo; Mice; Probes; Shape; Tomography;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Imaging: From Nano to Macro, 2007. ISBI 2007. 4th IEEE International Symposium on

Conference_Location

Arlington, VA

Print_ISBN

1-4244-0672-2

Electronic_ISBN

1-4244-0672-2

Type

conf

DOI

10.1109/ISBI.2007.356976

Filename

4193410