PATIENT-ADAPTIVE SPATIO-TEMPORAL MRI: FROM PARADIGM TO PARADISE AND BEYOND

Spatial and temporal resolution and image quality in dynamic MRI are severely limited by physical constraints of MRI on the rate of acquisition. The most challenging and important application is cardiac MR (CMR) imaging. We survey work on an explicit model-based methodology developed in our lab, enabling more than an order-of-magnitude reduction in the acquisition requirements in both single and multiple channel MRI, and providing guarantees on the quality of reconstruction subject to the modeling assumptions. Based on time-sequential sampling theory, the approach uses the models to (i) design a minimum redundancy acquisition sequence; and (ii) reconstruct a movie (cine) of the object. By adapting the model to the imaged subject, both acquisition and reconstruction are adaptive. Phantom studies with known ground truth, and in-vivo CMR experiments demonstrate unprecedented spatial and temporal resolutions.