The Cytotoxicity and OS-Mediated Toxicity of One Nanosize Titanium Dioxide

Author

Xu, Yang ; Xiao Guo-qiang ; Xiang Xiao-ling ; Yang Xu

Author_Institution

Lab. of Environ. Sci., Huazhong Normal Univ., Wuhan, China

fYear

2009

fDate

11-13 June 2009

Firstpage

1

Lastpage

3

Abstract

One kind of nanosize titanium dioxide (nano-TiO₂) was successfully made through anodization of titanium in this study, and its cytotoxicity and OS-mediated toxicity was detected by MTT, SOD and MDA assay in vitro and in vivo. The results showed that high does (0.8, 1.6 mg/mL) of this nano-TiO₂ can cause cytotoxicity and OS-mediated toxicity, and reverse dose-rate effect happened in the low and medium does (0.1, 0.2, 0.4 mg/mL) in the OS-mediated toxicity detection.

Keywords

anodisation; biohazards; cellular biophysics; chemical hazards; enzymes; nanotechnology; titanium compounds; toxicology; MDA assay; MTT assay; OS-mediated toxicity; SOD assay; TiO₂; anodization; cytotoxicity; in vitro study; in vivo study; nanosize titanium dioxide; reverse dose-rate effect; toxicity detection; Biochemistry; Biological materials; Gas detectors; In vitro; In vivo; Manufacturing; Nanotubes; Organic compounds; Surface morphology; Titanium;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on

Conference_Location

Beijing

Print_ISBN

978-1-4244-2901-1

Electronic_ISBN

978-1-4244-2902-8

Type

conf

DOI

10.1109/ICBBE.2009.5163586

Filename

5163586