• DocumentCode
    2527909
  • Title

    Pathway logic helping biologists understand and organize pathway information

  • Author

    Knapp, Merrill ; Briesemeiste, Linda ; Eker, Steven ; Lincoln, Patrick ; Poggio, Andy ; Talcott, Carolyn ; Laderoute, Keith

  • Author_Institution
    SRI Int., Menlo Park, CA, USA
  • fYear
    2005
  • fDate
    8-11 Aug. 2005
  • Firstpage
    155
  • Lastpage
    156
  • Abstract
    Pathway Logic is an application of techniques from formal methods to the modeling and analysis of signal transduction networks in mammalian cells. These signaling network models are developed using Maude, a symbolic language founded on rewriting logic. Network elements (reactions) are represented as rewrite rules. Models can be queried (analyzed) using the execution, search and model-checking tools of the Maude system. Collections of rules and initial states of interest form a novel kind of database where a biologist can record results of both curation and experiments.
  • Keywords
    biology computing; cellular biophysics; formal languages; rewriting systems; Maude system execution; Maude system model-checking tools; Maude system search; biology database; curation; experiments; formal methods; mammalian cells; model querying; network elements; pathway information organization; pathway logic; rewrite rules; rewriting logic; rules collections; signal transduction networks analysis; signal transduction networks modeling; signaling network model; symbolic language; Analytical models; Biological system modeling; Cells (biology); Cities and towns; Logic; Mathematical model; Particle measurements; Signal analysis; Time measurement; Visual databases;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Computational Systems Bioinformatics Conference, 2005. Workshops and Poster Abstracts. IEEE
  • Print_ISBN
    0-7695-2442-7
  • Type

    conf

  • DOI
    10.1109/CSBW.2005.103
  • Filename
    1540579