DocumentCode
2527909
Title
Pathway logic helping biologists understand and organize pathway information
Author
Knapp, Merrill ; Briesemeiste, Linda ; Eker, Steven ; Lincoln, Patrick ; Poggio, Andy ; Talcott, Carolyn ; Laderoute, Keith
Author_Institution
SRI Int., Menlo Park, CA, USA
fYear
2005
fDate
8-11 Aug. 2005
Firstpage
155
Lastpage
156
Abstract
Pathway Logic is an application of techniques from formal methods to the modeling and analysis of signal transduction networks in mammalian cells. These signaling network models are developed using Maude, a symbolic language founded on rewriting logic. Network elements (reactions) are represented as rewrite rules. Models can be queried (analyzed) using the execution, search and model-checking tools of the Maude system. Collections of rules and initial states of interest form a novel kind of database where a biologist can record results of both curation and experiments.
Keywords
biology computing; cellular biophysics; formal languages; rewriting systems; Maude system execution; Maude system model-checking tools; Maude system search; biology database; curation; experiments; formal methods; mammalian cells; model querying; network elements; pathway information organization; pathway logic; rewrite rules; rewriting logic; rules collections; signal transduction networks analysis; signal transduction networks modeling; signaling network model; symbolic language; Analytical models; Biological system modeling; Cells (biology); Cities and towns; Logic; Mathematical model; Particle measurements; Signal analysis; Time measurement; Visual databases;
fLanguage
English
Publisher
ieee
Conference_Titel
Computational Systems Bioinformatics Conference, 2005. Workshops and Poster Abstracts. IEEE
Print_ISBN
0-7695-2442-7
Type
conf
DOI
10.1109/CSBW.2005.103
Filename
1540579
Link To Document