Title :
Pathway logic helping biologists understand and organize pathway information
Author :
Knapp, Merrill ; Briesemeiste, Linda ; Eker, Steven ; Lincoln, Patrick ; Poggio, Andy ; Talcott, Carolyn ; Laderoute, Keith
Author_Institution :
SRI Int., Menlo Park, CA, USA
Abstract :
Pathway Logic is an application of techniques from formal methods to the modeling and analysis of signal transduction networks in mammalian cells. These signaling network models are developed using Maude, a symbolic language founded on rewriting logic. Network elements (reactions) are represented as rewrite rules. Models can be queried (analyzed) using the execution, search and model-checking tools of the Maude system. Collections of rules and initial states of interest form a novel kind of database where a biologist can record results of both curation and experiments.
Keywords :
biology computing; cellular biophysics; formal languages; rewriting systems; Maude system execution; Maude system model-checking tools; Maude system search; biology database; curation; experiments; formal methods; mammalian cells; model querying; network elements; pathway information organization; pathway logic; rewrite rules; rewriting logic; rules collections; signal transduction networks analysis; signal transduction networks modeling; signaling network model; symbolic language; Analytical models; Biological system modeling; Cells (biology); Cities and towns; Logic; Mathematical model; Particle measurements; Signal analysis; Time measurement; Visual databases;
Conference_Titel :
Computational Systems Bioinformatics Conference, 2005. Workshops and Poster Abstracts. IEEE
Print_ISBN :
0-7695-2442-7
DOI :
10.1109/CSBW.2005.103