• DocumentCode
    2528116
  • Title

    A parallel algorithm for clustering protein-protein interaction networks

  • Author

    Yang, Qiaofeng ; Lonardi, Stefano

  • Author_Institution
    Dept. of Comput. Sci., California Univ., Riverside, CA, USA
  • fYear
    2005
  • fDate
    8-11 Aug. 2005
  • Firstpage
    174
  • Lastpage
    177
  • Abstract
    The increasing availability of interaction graphs requires new resource-efficient tools capable of extracting valuable biological knowledge from these networks. In this paper we report on a novel parallel implementation of Girvan and Newman´s clustering algorithm that is capable of running on clusters of computers. Our parallel implementation achieves almost linear speed-up up to 32 processors and allows us to run this computationally intensive algorithm on large protein-protein interaction networks. Preliminary experiments show that the algorithm has very high accuracy in identifying functional related protein modules.
  • Keywords
    biochemistry; biology computing; molecular biophysics; pattern clustering; proteins; Girvan clustering algorithm; Newmans clustering algorithm; biological knowledge; functional related protein module; parallel algorithm; protein-protein interaction network; Availability; Bioinformatics; Biology computing; Clustering algorithms; Computer science; Concurrent computing; Fungi; Organisms; Parallel algorithms; Proteins;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Computational Systems Bioinformatics Conference, 2005. Workshops and Poster Abstracts. IEEE
  • Print_ISBN
    0-7695-2442-7
  • Type

    conf

  • DOI
    10.1109/CSBW.2005.13
  • Filename
    1540588