Title :
Creating a protein ontology resource
Author :
Sidhu, Amandeep S. ; Dillon, Tharam S. ; Chang, Elizabeth
Author_Institution :
Fac. of Inf. Technol., Univ. of Technol., Sydney, NSW, Australia
Abstract :
Protein Data Integration approaches at the moment considers data sources as data repositories, but not as applications; which in turn may embody complex interactions with other data sources. Current approaches do not provide methods both for generic mapping protein data representation, depicting interactions in data it describes and for interfacing existing data. The proposed Protein Ontology shows the value of hierarchy and relationships present in proteomics data. The creation of a Protein Ontology provides understanding of diverse types of data like: (1) Protein Entry Details, (2) 3D Structural Representations of Proteins, (3) Structural Folds and domains conserved in proteins, (4) Functional Domains and Families created based on Physiological and Pathological Functions of Proteins, and (5) Various Constraints like Genetic Defects and Chemical Properties of Cell that affect Final Stable Molecular Structure of Protein. Protein Ontology describes the concepts of interest in protein complex mechanisms and proteomics process.
Keywords :
biochemistry; biology computing; cellular biophysics; data structures; diseases; genetics; molecular biophysics; proteins; 3D structural representations; chemical property; data source; embody complex interaction; functional domains; generic mapping protein data representation; genetic defect; pathological function; physiological function; protein data integration; protein entry details; protein ontology resource; proteomics data; structural folds; Australia; Bioinformatics; Data mining; Databases; Information systems; Information technology; Ontologies; Proteins; Proteomics; Vocabulary; Biomedical Ontologies; Biomedical Systems; Data Integration; Protein Informatics; Protein Ontology; Systems Biology.;
Conference_Titel :
Computational Systems Bioinformatics Conference, 2005. Workshops and Poster Abstracts. IEEE
Print_ISBN :
0-7695-2442-7
DOI :
10.1109/CSBW.2005.46