Towards quantification of biocompatibility: Monitoring ingrowth behavior of biomaterials in tissue with a microsensor implant

Author

Kubon, M. ; Moschallski, M. ; Ensslen, T. ; Link, G. ; Werner, S. ; Burkhardt, C. ; Hartmann, H. ; Schlosshauer, B. ; Urban, G. ; Stelzle, M.

Author_Institution

NMI Natural & Med. Inst., Univ. of Tuebingen, Reutlingen, Germany

fYear

2011

fDate

5-9 June 2011

Firstpage

1935

Lastpage

1937

Abstract

We introduce a microsensor implant (MSI) comprising microsensors for dissolved oxygen, pH and electrical impedance to monitor ingrowth behavior of biomaterial coatings into tissue. The chorioallantoic membrane (CAM) of ex ovo transferred avian embryos served as a physiological tissue environment. Here, different signal progressions during ingrowth could be observed in a time period of 3-4 days. We tested biodegradable poly(DL-lactide-co-glycolide) and biostable plasma-polymerized coatings compared to an uncoated MSI.

Keywords

biological tissues; biomedical materials; biosensors; chemical sensors; coatings; microsensors; polymers; prosthetics; CAM; MSI; biocompatibility quantification; biodegradable poly(DL-lactide-co-glycolide) coating; biomaterial coating ingrowth behavior; biomaterial ingrowth behavior monitoring; biostable plasma polymerized coating; chorioallantoic membrane; dissolved oxygen microsensor; electrical impedance microsensor; ex ovo transferred avian embryos; microsensor implant; pH microsensor; physiological tissue environment; signal progression; Biomedical monitoring; Coatings; Impedance; Implants; Materials; Microsensors; Biocompatibility; Biomaterial; CAM-Assay; Chemosensor; Implant; Microsensor;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International

Conference_Location

Beijing

ISSN

Pending

Print_ISBN

978-1-4577-0157-3

Type

conf

DOI

10.1109/TRANSDUCERS.2011.5969289

Filename

5969289