Title :
Towards quantification of biocompatibility: Monitoring ingrowth behavior of biomaterials in tissue with a microsensor implant
Author :
Kubon, M. ; Moschallski, M. ; Ensslen, T. ; Link, G. ; Werner, S. ; Burkhardt, C. ; Hartmann, H. ; Schlosshauer, B. ; Urban, G. ; Stelzle, M.
Author_Institution :
NMI Natural & Med. Inst., Univ. of Tuebingen, Reutlingen, Germany
Abstract :
We introduce a microsensor implant (MSI) comprising microsensors for dissolved oxygen, pH and electrical impedance to monitor ingrowth behavior of biomaterial coatings into tissue. The chorioallantoic membrane (CAM) of ex ovo transferred avian embryos served as a physiological tissue environment. Here, different signal progressions during ingrowth could be observed in a time period of 3-4 days. We tested biodegradable poly(DL-lactide-co-glycolide) and biostable plasma-polymerized coatings compared to an uncoated MSI.
Keywords :
biological tissues; biomedical materials; biosensors; chemical sensors; coatings; microsensors; polymers; prosthetics; CAM; MSI; biocompatibility quantification; biodegradable poly(DL-lactide-co-glycolide) coating; biomaterial coating ingrowth behavior; biomaterial ingrowth behavior monitoring; biostable plasma polymerized coating; chorioallantoic membrane; dissolved oxygen microsensor; electrical impedance microsensor; ex ovo transferred avian embryos; microsensor implant; pH microsensor; physiological tissue environment; signal progression; Biomedical monitoring; Coatings; Impedance; Implants; Materials; Microsensors; Biocompatibility; Biomaterial; CAM-Assay; Chemosensor; Implant; Microsensor;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International
Conference_Location :
Beijing
Print_ISBN :
978-1-4577-0157-3
DOI :
10.1109/TRANSDUCERS.2011.5969289
