High-Q in-plane resonance-mode cantilever bio/chemical sensor for real-time detection in liquids

Author

Tao, Y.H. ; Wei, C.Z. ; Yu, H.T. ; Xu, P.C. ; Xu, T.G. ; Xiong, B. ; Li, Xinxin

Author_Institution

State Key Lab. of Transducer Technol., & Sci., Chinese Acad. of Sci., Shanghai, China

fYear

2011

fDate

5-9 June 2011

Firstpage

946

Lastpage

949

Abstract

Reported is an lateral-mode resonant cantilever sensor that features a much depressed liquid drag force, thereby, achieving a much higher quality factor of 249 in water and higher specific mass sensitivity in liquids, compared with traditional out-of-plane resonant cantilevers. With 8.8Hz/pg sensitivity calibrated by specific binding streptavidin-labled Dynabeads with the biotin-immobilized cantilever in Phosphate Buffered Saline (PBS) solution, specific-antibody immobilized cantilevers have real-time detected E. coli in PBS solution. Real-time detection of Hg²⁺ ions in aqueous Hg(NO₃)₂ is also carried out by using the sensing-group-modified cantilevers, resulting in a finer noise-limited resolution than 100ppb.

Keywords

Q-factor; biosensors; cantilevers; chemical sensors; mercury compounds; microorganisms; E. coli; Hg(NO₃)₂; Phosphate Buffered Saline solution; biosensor; chemical sensor; high-Q in-plane resonance-mode cantilever; lateral-mode resonant cantilever sensor; liquid drag force; mass sensitivity; quality factor; real-time detection; streptavidin-labled Dynabead; Ions; Q factor; Real time systems; Resonant frequency; Sensitivity; Sensors; Surface treatment; Detection in liquids; E. coli; Hg²⁺ ions in water; In-plane resonance mode; Microcantilever sensors; Quality factor;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International

Conference_Location

Beijing

ISSN

Pending

Print_ISBN

978-1-4577-0157-3

Type

conf

DOI

10.1109/TRANSDUCERS.2011.5969319

Filename

5969319