Title :
High-Q in-plane resonance-mode cantilever bio/chemical sensor for real-time detection in liquids
Author :
Tao, Y.H. ; Wei, C.Z. ; Yu, H.T. ; Xu, P.C. ; Xu, T.G. ; Xiong, B. ; Li, Xinxin
Author_Institution :
State Key Lab. of Transducer Technol., & Sci., Chinese Acad. of Sci., Shanghai, China
Abstract :
Reported is an lateral-mode resonant cantilever sensor that features a much depressed liquid drag force, thereby, achieving a much higher quality factor of 249 in water and higher specific mass sensitivity in liquids, compared with traditional out-of-plane resonant cantilevers. With 8.8Hz/pg sensitivity calibrated by specific binding streptavidin-labled Dynabeads with the biotin-immobilized cantilever in Phosphate Buffered Saline (PBS) solution, specific-antibody immobilized cantilevers have real-time detected E. coli in PBS solution. Real-time detection of Hg2+ ions in aqueous Hg(NO3)2 is also carried out by using the sensing-group-modified cantilevers, resulting in a finer noise-limited resolution than 100ppb.
Keywords :
Q-factor; biosensors; cantilevers; chemical sensors; mercury compounds; microorganisms; E. coli; Hg(NO3)2; Phosphate Buffered Saline solution; biosensor; chemical sensor; high-Q in-plane resonance-mode cantilever; lateral-mode resonant cantilever sensor; liquid drag force; mass sensitivity; quality factor; real-time detection; streptavidin-labled Dynabead; Ions; Q factor; Real time systems; Resonant frequency; Sensitivity; Sensors; Surface treatment; Detection in liquids; E. coli; Hg2+ ions in water; In-plane resonance mode; Microcantilever sensors; Quality factor;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International
Conference_Location :
Beijing
Print_ISBN :
978-1-4577-0157-3
DOI :
10.1109/TRANSDUCERS.2011.5969319
