Label-free real time imaging of neural communication using acetylcholine image sensor

Author

Takenaga, Shoko ; Tamai, Yui ; Hirai, Kengo ; Takahashi, Kazuhiro ; Sakurai, Takashi ; Terakawa, Susumu ; Ishida, Makoto ; Okumura, Koichi ; Sawada, Kazuaki

Author_Institution

Dept. of Electr. & Electron. Inf. Eng., Toyohashi Univ. of Technol., Toyohashi, Japan

fYear

2011

fDate

5-9 June 2011

Firstpage

954

Lastpage

957

Abstract

Release of acetylcholine (ACh) by a local K⁺ ion stimulation to neurons was successfully imaged using charge transfer type label-free ACh image sensor. In the non-stimulation area, the ACh release from the neurons was observed and the released ACh gradually diffused with time. These data suggest that the images of ACh release induced by local depolarization are involved in the propagation signals mediated by the neurotransmission at the nerve terminals. This report demonstrates the prospect for the label-free neural communication imaging for the first time.

Keywords

biomembrane transport; charge exchange; image sensors; neurophysiology; organic compounds; positive ions; potassium; ACh image sensor; K⁺; acetylcholine image sensor; charge transfer; label-free real time imaging; local depolarization; neural communication; neurons; neurotransmission; potassium+ ion stimulation; Biochemistry; Charge transfer; Image sensors; Neurons; Pixel; Real time systems; ACh image sensor; label free; neural communication imaging;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International

Conference_Location

Beijing

ISSN

Pending

Print_ISBN

978-1-4577-0157-3

Type

conf

DOI

10.1109/TRANSDUCERS.2011.5969337

Filename

5969337