Recording of neural activity of mouse retinal ganglion cells by means of an integrated high-density microelectrode array

The retina is responsible for the processing and encoding of visual stimuli into neural spike trains. The output module of the retina is composed of a single layer of retinal ganglion cells (RGCs) that transmit the encoded information to higher centers in the brain. Using a high-density complementary metal-oxide-semiconductor (CMOS)-based microelectrode array (MEA) to scan the RGC layer, we have shown that it is possible to record and sort the spikes produced by selected RGCs. This technique provides a high spatio-temporal-resolution readout of the neural circuitry and function of the retina.