Title :
Recording of neural activity of mouse retinal ganglion cells by means of an integrated high-density microelectrode array
Author :
Jones, I.L. ; Fiscella, M. ; Frey, U. ; Jäckel, D. ; Müller, J. ; Roscic, B. ; Streichan, R. ; Hierlemann, A.
Author_Institution :
Bio Eng. Lab., ETH Zurich, Basel, Switzerland
Abstract :
The retina is responsible for the processing and encoding of visual stimuli into neural spike trains. The output module of the retina is composed of a single layer of retinal ganglion cells (RGCs) that transmit the encoded information to higher centers in the brain. Using a high-density complementary metal-oxide-semiconductor (CMOS)-based microelectrode array (MEA) to scan the RGC layer, we have shown that it is possible to record and sort the spikes produced by selected RGCs. This technique provides a high spatio-temporal-resolution readout of the neural circuitry and function of the retina.
Keywords :
CMOS integrated circuits; biomedical electrodes; eye; microelectrodes; neurophysiology; CMOS microelectrode array; complementary metal-oxide-semiconductor; integrated high-density microelectrode array; mouse retinal ganglion cell; neural activity recording; neural circuitry; neural spike train; spatiotemporal resolution; visual stimuli; Arrays; Electrodes; Mice; Neurons; Retina; Sorting; Visualization; CMOS; Microelectrode array (MEA); electrogenic cells; multielectrode array; neurons; retina; retinal ganglion cell (RGC);
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International
Conference_Location :
Beijing
Print_ISBN :
978-1-4577-0157-3
DOI :
10.1109/TRANSDUCERS.2011.5969341
