Multi-site electroretinogram recordings inside isolated mouse retina using flexible spatially arranged microelectrode probes

This paper presents flexible spatially arranged microelectrode probes to allow multi-site electroretinogram (ERG) recordings in the isolated mouse retina. Out-of-plane microelectrode probes standing on a substrate have gradation in height. Wire-bonding-based probe technology makes it possible to provide the flexible probes. Retina tissue has laminar structures composed of ganglion, bipolar and photoreceptor cells. We would understand each cellular activity caused by the construction process of retina, because the developed probes can directly stimulate and record cells at multiple point inside the isolated retina tissue. Through experiments on mouse retina, we show that the microelectrode probe arrays can successfully record ERG elicited by a flash light.