Title :
Theoretical study of pressure and cosolvent effects on the solvation structure of staphylococcal nuclease
Author :
Yamazaki, Takeshi ; Kovalenko, Andriy
Author_Institution :
Alberta Univ., Edmonton, Alta., Canada
Abstract :
Integral equation theory for molecular liquids, three-dimensional reference interaction site model (3D-RISM), is used to study pressure and cosolvent effects on the solvation structure of staphylococcal nuclease (SNase). Solvation structure, partial molar volume, and partial molar volume-compressibility, which relates to the response of solvation structure with respect to the pressure, around SNase are discussed.
Keywords :
biochemistry; integral equations; molecular biophysics; proteins; solvation; solvent effects; cosolvent effects; integral equation theory; molecular liquids; partial molar volume-compressibility; pressure effects; proteins; solvation structure; staphylococcal nuclease; three-dimensional reference interaction site model; Amino acids; Biological systems; Integral equations; Liquids; Nanotechnology; Pressure effects; Proteins; Solvents; Stability; Thermodynamics;
Conference_Titel :
MEMS, NANO and Smart Systems, 2005. Proceedings. 2005 International Conference on
Print_ISBN :
0-7695-2398-6
DOI :
10.1109/ICMENS.2005.123
