Delivery of an anti-cancer drug from a magnetically controlled MEMS device show cytotoxicity in PC3 and HUVEC cells

Author

Pirmoradi, F.N. ; Jackson, J. ; Burt, H. ; Chiao, M.

Author_Institution

Dept. of Mech. Eng., Univ. of British Columbia, Vancouver, BC, Canada

fYear

2011

fDate

5-9 June 2011

Firstpage

2831

Lastpage

2834

Abstract

We have developed a magnetically controlled MEMS drug delivery device for on-demand release of defined quantities of an anti-cancer drug, docetaxel (DTX). A drug-loaded micro reservoir (Ø6mm×550μm) is sealed by a 40μm-thick elastic magnetic PDMS (polydimethylsiloxane) membrane with a laser-drilled aperture (~100×100μm²). Discharge of the drug solution and the release rates are controlled by an external magnetic field. Controlled and reproducible release rates of DTX have been achieved for 35 days. We report on the cytotoxicity of the released drug from the device (monitored as cell viability) and show that DTX maintains cytotoxic effects for two months.

Keywords

bioMEMS; cancer; cellular biophysics; drug delivery systems; drugs; magnetomechanical effects; DTX; HUVEC cells; PC3 cells; anticancer drug delivery; cell viability; cytotoxicity; docetaxel; drug solution; drug-loaded micro reservoir; elastic magnetic PDMS; external magnetic field; laser-drilled aperture; magnetically controlled MEMS device; polydimethylsiloxane membrane; release rates; size 40 mum; Apertures; Drug delivery; Drugs; Magnetic devices; Magnetic fields; Micromechanical devices; Reservoirs; MEMS; active drug release; controlled drug delivery; docetaxel; magnetic actuation; on-demand;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International

Conference_Location

Beijing

ISSN

Pending

Print_ISBN

978-1-4577-0157-3

Type

conf

DOI

10.1109/TRANSDUCERS.2011.5969372

Filename

5969372