Title :
An integrated lobule-mimetic liver chip for testing hepatotoxicity
Author :
Chu, Y.J. ; Punde, T.H. ; Yang, S.M. ; Srinivasu, V.P. ; Shilpa, S. ; Chen, R.J. ; Liu, C.H.
Author_Institution :
Dept. of Power Mech. Eng., Nat. Tsing Hua Univ., Hsinchu, Taiwan
Abstract :
The current trend in personalized healthcare shows that medical care is becoming as individualized as possible. The goal is not only to provide customized diagnostic tests but also to target medicines and dosages more precisely and safely to each patient. Here in this article we report an integrated drug testing device based on lobule-mimetic liver pattern for testing in vitro drug toxicity. We aimed at achieving customized diagnostic tests by reconstructing and mimicking a liver pattern in vitro for predicting the in vivo drug hepatotoxicity.
Keywords :
bioMEMS; drug delivery systems; liver; microfluidics; toxicology; customized diagnostic tests; in vitro drug toxicity; integrated drug testing device; integrated lobule-mimetic liver chip; medical care; microfluidic chip; personalized healthcare; testing hepatotoxicity; Testing; Wet etching; Cell patterning; Dielectrophoresis; Gradient; Hepatotoxicity;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International
Conference_Location :
Beijing
Print_ISBN :
978-1-4577-0157-3
DOI :
10.1109/TRANSDUCERS.2011.5969388
