DocumentCode
2533035
Title
An integrated lobule-mimetic liver chip for testing hepatotoxicity
Author
Chu, Y.J. ; Punde, T.H. ; Yang, S.M. ; Srinivasu, V.P. ; Shilpa, S. ; Chen, R.J. ; Liu, C.H.
Author_Institution
Dept. of Power Mech. Eng., Nat. Tsing Hua Univ., Hsinchu, Taiwan
fYear
2011
fDate
5-9 June 2011
Firstpage
218
Lastpage
221
Abstract
The current trend in personalized healthcare shows that medical care is becoming as individualized as possible. The goal is not only to provide customized diagnostic tests but also to target medicines and dosages more precisely and safely to each patient. Here in this article we report an integrated drug testing device based on lobule-mimetic liver pattern for testing in vitro drug toxicity. We aimed at achieving customized diagnostic tests by reconstructing and mimicking a liver pattern in vitro for predicting the in vivo drug hepatotoxicity.
Keywords
bioMEMS; drug delivery systems; liver; microfluidics; toxicology; customized diagnostic tests; in vitro drug toxicity; integrated drug testing device; integrated lobule-mimetic liver chip; medical care; microfluidic chip; personalized healthcare; testing hepatotoxicity; Testing; Wet etching; Cell patterning; Dielectrophoresis; Gradient; Hepatotoxicity;
fLanguage
English
Publisher
ieee
Conference_Titel
Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International
Conference_Location
Beijing
ISSN
Pending
Print_ISBN
978-1-4577-0157-3
Type
conf
DOI
10.1109/TRANSDUCERS.2011.5969388
Filename
5969388
Link To Document