Title :
Optical phase to biological mass conversion for label-free interferometric sensing methods
Author :
Özkumur, Emre ; Yalcin, Ayca ; Cretich, Marina ; Damin, Francesco ; Lopez, Carlos ; Bergstein, David A. ; Goldberg, Bennett B. ; Chiari, Marcella ; Ünlü, M. Selim
Author_Institution :
Dept .of Electr. & Comput. Eng., Boston Univ., Boston, MA, USA
Abstract :
The conversion between the detected optical phase and the biological mass accumulated on the surface is determined using a label-free interferometric technique. The results demonstrate a linear phase/mass relationship for DNA and protein microarrays.
Keywords :
bioMEMS; biosensors; lab-on-a-chip; light interferometry; optical sensors; proteins; DNA microarray; biological mass conversion; label-free interferometric sensing methods; label-free interferometric technique; linear phase-mass relationship; optical phase; protein microarrays; Biomedical optical imaging; Biosensors; DNA; Fluorescence; Molecular biophysics; Optical interferometry; Optical sensors; Proteins; Refractive index; Solids;
Conference_Titel :
LEOS Annual Meeting Conference Proceedings, 2009. LEOS '09. IEEE
Conference_Location :
Belek-Antalya
Print_ISBN :
978-1-4244-3680-4
Electronic_ISBN :
1092-8081
DOI :
10.1109/LEOS.2009.5343181
