Title :
Fluorescence enhancement on reflecting substrates for microarray applications
Author :
Yalçin, Ayça ; Cretich, Marina ; di Carlo, G. ; Sola, Laura ; Monroe, Margo ; Selim Unlu, M. ; Chiari, Marcella
Author_Institution :
Dept. of Electr. & Comput. Eng., Boston Univ., Boston, MA, USA
Abstract :
In this study, we report on the utilization of layered substrates for increased performance of fluorescent-based detection schemes. Through optimization of layer thicknesses, we demonstrate that enhancement with respect to commonly used microscope slides is achieved for the collected fluorescence signal.
Keywords :
biomedical materials; biosensors; fluorescence; lab-on-a-chip; microsensors; optical films; optical sensors; optimisation; patient diagnosis; silicon; silicon compounds; SiO2-Si; fluorescence enhancement; fluorescent-based detection; layer thickness; microarray applications; optimization; reflecting substrates; Application software; Chemistry; Electromagnetic modeling; Fluorescence; Microscopy; Photobleaching; Reproducibility of results; Semiconductor thin films; Silicon; Substrates;
Conference_Titel :
LEOS Annual Meeting Conference Proceedings, 2009. LEOS '09. IEEE
Conference_Location :
Belek-Antalya
Print_ISBN :
978-1-4244-3680-4
Electronic_ISBN :
1092-8081
DOI :
10.1109/LEOS.2009.5343184
