Title :
Flexible intravascular thermal sensors to assess atherosclerosis-mediated changes in hemodynamics
Author :
Lee, Juhyun ; Jen, Nelson ; Yu, Fei ; Dai, Wangde ; Yu, Hongyu ; Hsiai, Tzung K.
Author_Institution :
Dept. of Biomed. Eng. & Cardiovascular Med., Univ. of Southern California, Los Angeles, CA, USA
Abstract :
In this study, we introduced an in vivo convective heat transfer-based micro-electromechanical system (MEMS) sensor that measured real-time experimental vascular shear stress values in the aortas of New Zealand White rabbits (n=4). Experiments were performed to measure flow profile changes in response to hyper-cholesterol diet and an irregular tachycardia condition. We have shown that these conditions induce shear stress changes indicative of pre-atherosclerosis regions by the MEMS thermal sensor.
Keywords :
biomechanics; biomedical equipment; biothermics; blood flow measurement; blood vessels; diseases; heat transfer; microsensors; shear flow; MEMS thermal sensor; New Zealand White rabbits; aorta; atherosclerosis; convective heat transfer; flow profile; hemodynamics; hypercholesterol diet; intravascular thermal sensor; irregular tachycardia condition; microelectromechanical system sensor; vascular shear stress value; Biomedical measurements; Hemodynamics; Micromechanical devices; Rabbits; Stress; Thermal sensors; Atherosclerosis; CFD; MEMS; shear stress; tachycardia;
Conference_Titel :
Health Care Exchanges (PAHCE), 2012 Pan American
Conference_Location :
Miami, FL
Print_ISBN :
978-1-4673-1135-9
DOI :
10.1109/PAHCE.2012.6233431
