Time-dependent cell membrane damage under mechanical tension: Experiments and modeling

This paper reports a study of cancer cell membrane damage during filtration caused by cell membrane tension. The membrane tension was induced when cells were captured on a microfabricated parylene-C filter during the constant-pressure-driven filtration. This work includes both experiments and modeling to explore the underlying biomechanics of the cell membrane damage. The developed model not only agrees with our time-dependent cell damage data, but also fits well with previous results on red blood cells reported by other groups.