Title :
A single chip micro-DNA-array system based on CMOS image sensor technology
Author :
Wang, Yijin ; Hsing, Ming ; Xu, Chen ; Li, Jiong ; Chan, Mansun
Author_Institution :
Dept. of Bioeng., Hong Kong Univ. of Sci. & Technol.
Abstract :
A micro-DNA-array based on integrated CMOS active pixel sensor (APS) technology is demonstrated. This system utilizes gold nano-particle binding to a DNA sample, which subsequently absorbed to the chip surface through the hybridization process when a matching between the DNA samples and DNA probes on the chip surface is found. The degree of DNA matching is reflected by the opacity of a certain location on the chip, which can be detected by the underlying CMOS APS array. The chip has been fabricated with a 0.5mum CMOS process and contains on-chip timing control, dynamic range enhancement by pulse-width modulation and correlated sampling. The system can detect DNA sample with extremely low concentration under ordinary light source
Keywords :
CMOS image sensors; biosensors; 0.5 micron; CMOS active pixel sensor; CMOS image sensor; correlated sampling; gold nanoparticle binding; micro-DNA-array system; on-chip timing control; pulse width modulation; CMOS image sensors; CMOS process; CMOS technology; DNA; Dynamic range; Gold; Probes; Pulse modulation; Space vector pulse width modulation; Timing;
Conference_Titel :
Circuits and Systems, 2006. ISCAS 2006. Proceedings. 2006 IEEE International Symposium on
Conference_Location :
Island of Kos
Print_ISBN :
0-7803-9389-9
DOI :
10.1109/ISCAS.2006.1693040
