Portable oral cancer detection using miniature confocal imaging probe with large field of view

We demonstrate MEMS micromirror enabled hand-held confocal imaging probe for portable oral cancer detection, where large field of view (FOV) is achieved through the lissajous scanning operation of the MEMS mirror. The imaging speed up to 2 frames per second was demonstrated with the improved Labview and Java based data acquisition and control programs. We also examined the axial resolution (3.4 um) and large FOV (1mm × 1mm) through mosaic imaging using the handheld imaging probe. Multiple clinical samples, including neoplastic lesion tissues of giant cell fibroma, epithelial ossifying fibroma, the fibroma inside the paraffin box and ex-vivo gross tissue, were scanned using the compact imaging modalities. The quality of the images acquired is comparable to those from commercial microscopes.