DocumentCode
2550741
Title
A Promising method for fast evaluating protein structure similarity
Author
Liu, Ying
Author_Institution
Found. Dept., ZheJiang TongJi Vocational Coll. of Sci. & Technol., Hang Zhou, China
fYear
2012
fDate
29-31 May 2012
Firstpage
2863
Lastpage
2865
Abstract
According to a ligand binding site, screening protein structural database may provide the lead information to accelerate drug discovery research. In this study we propose a novel approach MIIF based on the method protein folding shape code (PFSC), is applied to discover the similar binding site area of a protein related to the known drug target area of a ligand.
Keywords
bioinformatics; molecular biophysics; pattern matching; proteins; MIIF approach; PFSC; drug discovery research; drug target area; lead information; ligand binding site; protein folding shape code; protein structural database; protein structure similarity; Amino acids; Correlation; Drugs; Indexes; Matrices; Proteins; Blosum score; CC score; PFSC; key residue score;
fLanguage
English
Publisher
ieee
Conference_Titel
Fuzzy Systems and Knowledge Discovery (FSKD), 2012 9th International Conference on
Conference_Location
Sichuan
Print_ISBN
978-1-4673-0025-4
Type
conf
DOI
10.1109/FSKD.2012.6234229
Filename
6234229
Link To Document