Title :
CMOS APS in pre-clinical science: Next generation disruptive technology for multi-modality imaging
Author :
Esposito, M. ; Bailey, Alexander ; Newcombe, S. ; Anaxagoras, T. ; Allinson, N.M. ; Wells, Kevin
Author_Institution :
Centre for Vision, Speech & Signal Process., Univ. of Surrey, Guildford, UK
fDate :
Oct. 27 2012-Nov. 3 2012
Abstract :
A new large area CMOS Active Pixel Sensor has been developed as single platform technology to be used across a range of ionizing and non-ionizing imaging applications in preclinical science, ranging from imaging of protein sequences to functional analysis of radio-labeled tissue sections. We present the first images of chemiluminescence detection in western blotting with a room temperature CMOS APS. Detection performance in western blotting have been compared with the gold standard detection medium, film emulsion, showing higher dynamic range and sensitivity with this new device. We also report on our first images of [125I]Epibatidine autoradiography of brain sections using a novel large area CMOS APS.
Keywords :
CMOS image sensors; biochemistry; biological tissues; chemical sensors; chemiluminescence; emulsions; molecular biophysics; proteins; radioisotope imaging; radioisotopes; 125I Epibatidine autoradiography; CMOS active pixel sensor; brain section; chemiluminescence detection; detection performance; film emulsion; multimodality imaging; next generation disruptive technology; nonionizing imaging application; protein sequence imaging; radio-labeled tissue section; room temperature CMOS APS; temperature 293 K to 298 K; western blotting; APS; Autoradiography; CMOS; Chemiluminescence detection; Large area image sensors; Life science imaging applications; Pre-clinical imaging; semiconductor devices;
Conference_Titel :
Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2012 IEEE
Conference_Location :
Anaheim, CA
Print_ISBN :
978-1-4673-2028-3
DOI :
10.1109/NSSMIC.2012.6551442
